----- Original Message -----
From: Eliane Gluckman
To: petr.sedlacek@lfmotol.cuni.cz
Sent: Friday, October 28, 2005 2:00 PM
Subject: Patient Mracek

Dear Dr Sedlacek and Dr Star
I have seen at my consultation your patient Mracek Ilja who is affected
by a severe and rare form of Fanconi anemia  with a FANC B mutation. The
family came to our unit for an indication of Bone Marrow transplant with
an unrelated donor. They are very anxious because they are aware of the
poor prognosis of unrelated transplants in FA. I think that this patient
should be transplanted as soon as possible because he is already very
aplastic and there is a high risk of leukemia. The donor could be either
an unrelated 10/10 matched donor or a cord blood donor . We have been
changing our protocols very often , the last one includes low dose
busulfan, low dose cyclophosphamide, Fludarabine and ATG for
conditioning and cyclosporine MMF for GVH prevention. If you agree we
can transplant this patient in our unit and send him back to you as soon
as it is possible. To do that we need an agreement from you. I really
think that transplant in this particular disease needs a lot of
experience because the DNA defect  leads to major complications
especially if GVH occurs. We have now transplanted more than 150
patients with FA although we are very far from having 100%success rate
we have been slowly improving with time. If you choose to transplant
this patient in your center we would of course give you the best advise
 we can if you need it. Hope to have a prompt answer from you . The
family will probably enter in contact with you. Sincerely  Best regards
Eliane Gluckman